2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester
• CAS No.: 904887-82-7
• Molecular Formula: C₂₆H₂₁O₃P
• Molecular Weight: 412.425
• Mol file: 904887-82-7.mol

Synonyms:2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester

Chemical Property of 2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester

There total 3 articles about 2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + (+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl (155566-49-7) → 2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester (904887-82-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate; under 760 Torr;

DOI:10.1055/s-2006-933100

Reference yield:

2,2'-dihydroxybiphenyl (1806-29-7) → 2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester (904887-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / pyridine

2: 83 percent / dppb; i-Pr₂EtN / Pd(OAc)2

3: 84 percent / dppb; i-Pr₂EtN / Pd(OAc)2 / 760 Torr

With pyridine; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate;

DOI:10.1055/s-2006-933100

Reference yield:

2,2'-bis-<<(trifluoromethyl)sulfonyl>oxy>biphenyl (17763-95-0) → 2'-(diphenyl-phosphinoyl)-biphenyl-2-carboxylic acid methyl ester (904887-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / dppb; i-Pr₂EtN / Pd(OAc)2

2: 84 percent / dppb; i-Pr₂EtN / Pd(OAc)2 / 760 Torr

With N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate;

DOI:10.1055/s-2006-933100

upstream raw materials:

methanol

carbon monoxide

(+/-)-2-(diphenylphosphinyo)-2'-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

2,2'-dihydroxybiphenyl

Downstream raw materials:

2'-diphenylphosphanyl-biphenyl-2-carboxylic acid methyl ester

(S)-2'-(diphenylphosphoryl)-N-(1-hydroxy-3-methylbutan-2-yl)biphenyl-2-carboxamide

(S)-2'-(diphenylphosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

(S)-2'-(diphenylphosphoryl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)biphenyl-2-carboxamide