2-AMINO-5-BROMO-6-METHYLPYRAZINE

Base Information

• Chemical Name: 2-AMINO-5-BROMO-6-METHYLPYRAZINE
• CAS No.: 74290-69-0
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188.027
• Hs Code.: 2933990090
• Mol file: 74290-69-0.mol

Synonyms:Pyrazinamine,5-bromo-6-methyl- (9CI);2-Amino-5-bromo-6-methylpyrazine;5-Bromo-6-methylpyrazin-2-amine;

Chemical Property of 2-AMINO-5-BROMO-6-METHYLPYRAZINE

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.627
• Boiling Point: 273.775 °C at 760 mmHg
• PKA: 1.96±0.10(Predicted)
• Flash Point: 119.375 °C
• PSA: 51.80000
• Density: 1.7 g/cm³
• LogP: 1.71090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-bromo-6-methylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-BROMO-6-METHYLPYRAZINE

There total 6 articles about 2-AMINO-5-BROMO-6-METHYLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-methylpyrazin-2-amine (5521-56-2) → (5-bromo-6-methyl-pyrazin-2-yl)amine (74290-69-0) + 3,5-dibromo-6-methylpyrazin-2-ylamine (74290-66-7)

Guidance literature:

With pyridine; bromine; In chloroform; for 0.5h; Ambient temperature; in the dark;

Reference yield: 36.0%

6-methylpyrazin-2-amine (5521-56-2) → (5-bromo-6-methyl-pyrazin-2-yl)amine (74290-69-0)

Guidance literature:

With N-Bromosuccinimide; In water; dimethyl sulfoxide; at 20 ℃; for 5.25h; Inert atmosphere; Cooling with ice;

Reference yield:

2-amino-6-methylpyrazine-3-carboxylic acid (6761-50-8) → (5-bromo-6-methyl-pyrazin-2-yl)amine (74290-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / 1,2,3,4-tetrahydro-naphthalene / 1 h / 202 °C

2: bromine, pyridine / CHCl₃ / 0.5 h / Ambient temperature; in the dark

With pyridine; bromine; In tetralin; chloroform;

upstream raw materials:

6-methylpyrazin-2-amine

2-amino-6-methylpyrazine-3-carboxylic acid

2-chloro-6-methylpyrazine

2-(6-chloro-pyrazin-2-yl)-malonic acid diethyl ester

Downstream raw materials:

5-amino-3-methylpyrazine-2-carbonitrile

Refernces

• 1、 -. "Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors". Paragraph 02222. . Retrieved 2014/01/07.
• 2、 Sato, Nobuhiro. "Studies on Pyrazines. 6. A Facile Separation Method for a Mixture of the Isomeric 2-Amino-3,5, and 6-methylpyrazines". . p. 143 - 147. Retrieved 2007/10/02.