6761-50-8

Basic information

• Product Name: Pyrazinecarboxylic acid, 3-amino-5-methyl- (7CI,8CI,9CI)
• Synonyms: Pyrazinecarboxylic acid, 3-amino-5-methyl- (7CI,8CI,9CI);3-AMINO-5-METHYL-2-PYRAZINECARBOCYLIC ACID;3-aMino-5-Methylpyrazine-2-carboxylic acid;2-Pyrazinecarboxylic acid, 3-aMino-5-Methyl-;3-AMINO-5-METHYLPYRAZINE-2-CARBOXYLIC ACID HCL;3-Amino-5-methyl-2-pyrazinecarboxylic acid
• CAS NO: 6761-50-8
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Mol File: 6761-50-8.mol

Chemical Properties

• Melting Point: 211 °C
• Boiling Point: 387.7 °C at 760 mmHg
• Flash Point: 188.3 °C
• Appearance: /
• Density: 1.431 g/cm³
• Vapor Pressure: 1.05E-06mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C
• PKA: 4.14±0.10(Predicted)
• CAS DataBase Reference: Pyrazinecarboxylic acid, 3-amino-5-methyl- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxylic acid, 3-amino-5-methyl- (7CI,8CI,9CI)(6761-50-8)
• EPA Substance Registry System: Pyrazinecarboxylic acid, 3-amino-5-methyl- (7CI,8CI,9CI)(6761-50-8)

Safety Data

• Hazardous Substances Data: 6761-50-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyrazinecarboxylic acid, 3-amino-5-methyl(7CI,8CI,9CI) is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of new drugs and medical treatments, contributing to advancements in healthcare and medicine.
Used in Chemical Research:
Pyrazinecarboxylic acid, 3-amino-5-methyl (7CI,8CI,9CI) also serves as a valuable resource in chemical research, where it can be used to study the properties and reactions of similar compounds. Its versatility in chemical synthesis makes it an important tool for researchers in the field.
Used in Agriculture:
Although not explicitly mentioned in the provided materials, the potential applications of Pyrazinecarboxylic acid, 3-amino-5-methyl(7CI,8CI,9CI) in agriculture could include its use in the development of new agrochemicals or as a component in the synthesis of compounds used in crop protection and enhancement.
Safety Precautions:
As with any chemical compound, it is crucial to observe proper handling and safety precautions when using Pyrazinecarboxylic acid, 3-amino-5-methyl-. This helps to prevent potential hazards and health risks associated with its use, ensuring the safety of both individuals and the environment.

InChI:InChI=1/C6H7N3O2/c1-3-2-8-4(6(10)11)5(7)9-3/h2H,1H3,(H2,7,9)(H,10,11)

Upstream product

• 50627-49-1 3-amino-5-methyl-pyrazine-2-carboxylic acid amide 
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• 623-11-0 1-methyl-4-nitrosobenzene 
• 13401-38-2 7-methyl-pteridine-2,4-diol 
• 117883-59-7 6-methyl-1,2-dihydro-pyrazolo[3,4-b]pyrazin-3-one 

Downstream Products

• 5521-56-2 6-methylpyrazin-2-amine 
• 6298-35-7 sulfanilic acid-(6-methyl-pyrazin-2-ylamide) 
• 866561-44-6 (3-amino-5-methylpyrazin-2-yl)methanol 
• 74290-69-0 (5-bromo-6-methyl-pyrazin-2-yl)amine 

Relevant articles and documents

Organic compounds

The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar′, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.

THIAZOLIUMS AS TRANSKETOLASE INHIBITORS

The present invention provides N-3'-pyridylmethyl or N-2'-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X- are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

Research on heterocyclic compounds. XXXVII. Synthesis and antiinflammatory activity of methyl-substituted imidazo[1,2-a]pyrazine derivatives

A series of methyl-substituted imidazo[1,2-a]pyrazines 8 bearing a carboxylic acid group on the imidazole ring were synthesized. The structures of new compounds were confirmed by 1H- and 13C-NMR spectral data; the correct assignment of carbon resonances was made by means of HETCOR and COLOC experiments. Antiinflammatory, analgesic and ulcerogenic activities in vivo were evaluated and compared with those of antiinflammatory imidazopyrazines (2 and 3) and indomethacin. The inhibitory action on cyclooxygenase activity was evaluated in vitro. Compounds 8 were found to be less potent than indomethacin in these assays. SARs are discussed.