(2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

Base Information

Chemical Name:(2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate
CAS No.:889663-97-2
Molecular Formula:C₂₃H₂₅F₂N₃O₅
Molecular Weight:461.465
Hs Code.:

Synonyms:(2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

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Chemical Property of (2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

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Technology Process of (2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

There total 4 articles about (2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (2S,4R)-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-2-trifluoromethanesulfonyloxy-butyl ester

: 889663-97-2
(2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm060066q

Reference yield:

: 885621-52-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

: 889663-97-2
(2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 2 h / -25 °C

2: 2.66 g / sodium azide / dimethylformamide / 20 °C

With pyridine; sodium azide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060066q

Reference yield:

: 98-88-4
benzoyl chloride

: 889663-97-2
(2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 2 h / -78 °C

2: pyridine / CH₂Cl₂ / 2 h / -25 °C

3: 2.66 g / sodium azide / dimethylformamide / 20 °C

With pyridine; sodium azide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060066q