(2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

Base Information

Chemical Name:(2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate
CAS No.:889664-07-7
Molecular Formula:C₂₆H₃₅F₂N₃O₅Si
Molecular Weight:535.663
Hs Code.:

Synonyms:(2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

Suppliers and Price of (2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

There total 6 articles about (2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 889663-98-3
(2R,4R,5R)-2-azido-4-O-benzyl-3,3-difluoro-5,6-dihydroxyhex-1-yl benzoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 889664-07-7
(2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1021/jm060066q

Reference yield:

: 885621-52-3
(2S,4R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

: 889664-07-7
(2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 2 h / -25 °C

2: 2.66 g / sodium azide / dimethylformamide / 20 °C

3: 95 percent / aq. AcOH / 3 h / 50 °C

4: 86 percent / imidazole / dimethylformamide / 1 h / 0 °C

With pyridine; 1H-imidazole; sodium azide; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060066q

Reference yield:

: 889663-97-2
(2R,4R)-2-azido-4-O-benzyl-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3,3-difluorobut-1-yl benzoate

: 889664-07-7
(2R,4R,5R)-2-azido-4-O-benzyl-6-(tert-butyldimethylsilyloxy)-3,3-difluoro-5-hydroxyhex-1-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. AcOH / 3 h / 50 °C

2: 86 percent / imidazole / dimethylformamide / 1 h / 0 °C

With 1H-imidazole; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm060066q