N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide

Base Information

Chemical Name:N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide
CAS No.:1442473-81-5
Molecular Formula:C₂₆H₂₄FN₅O₃
Molecular Weight:473.507
Hs Code.:

Synonyms:N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide

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Chemical Property of N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide

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Technology Process of N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide

There total 12 articles about N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 60-35-5
acetamide

: 1442471-10-4
1-(5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea

: 1442473-81-5
N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide

Guidance literature:: acetamide; 1-(5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-phenylurea; With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; potassium phosphate; In 1,4-dioxane; for 0.25h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1442473-81-5
N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

4.1: triethylamine / tetrahydrofuran / 20 °C

5.1: potassium phosphate; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole / 1,4-dioxane / 0.25 h / Inert atmosphere

5.2: 80 °C

With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; manganese(IV) oxide; aluminum oxide; potassium fluoride; potassium phosphate; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 959162-99-3
(6-chloro-4-(ethylamino)pyridin-3-yl)methanol

: 1442473-81-5
N-(1-ethyl-3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

3.1: triethylamine / tetrahydrofuran / 20 °C

4.1: potassium phosphate; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole / 1,4-dioxane / 0.25 h / Inert atmosphere

4.2: 80 °C

With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; manganese(IV) oxide; aluminum oxide; potassium fluoride; potassium phosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;