Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Base Information

• Chemical Name: Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester
• CAS No.: 80817-51-2
• Molecular Formula: C₄₂H₄₄ClN₈O₈PSi
• Molecular Weight: 883.372

Synonyms:Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Chemical Property of Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

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Technology Process of Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

There total 3 articles about Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzotriazol-1-ol (2592-95-2) → Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (80817-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 0.5 h / 20 °C

With pyridine; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)91336-X

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (80817-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 0.5 h / 20 °C

With pyridine; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)91336-X

Reference yield:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate (80817-46-5) + N-{9-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-6-hydroxy-9H-purin-2-yl}-2,2-diphenyl-acetamide (80817-49-8) → Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (80817-51-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(01)91336-X

upstream raw materials:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate

N-{9-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-6-hydroxy-9H-purin-2-yl}-2,2-diphenyl-acetamide

benzotriazol-1-ol

2-chlorophenyl dichlorophosphate

Downstream raw materials:

Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2-diphenylacetylamino-6-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2,2,2-tribromo-ethyl ester

C₆₀H₆₃ClN₇O₁₃PSi

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