2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester
CAS No.:340774-82-5
Molecular Formula:C₂₂H₃₀N₂O₅
Molecular Weight:402.491
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

Synonyms:2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

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Technology Process of 2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

There total 12 articles about 2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-2-Amino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

: 340774-82-5
2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/b008970m

Reference yield:

: 37439-79-5
2-allyl-3-acetamidophenol

: 340774-82-5
2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 82 percent / K₂CO₃ / acetone / Heating

2.1: 81 percent / HCl / 2 h / Heating

3.1: 72 percent / toluene / 24 h / Heating

4.1: 74 percent / OsO₄; NMO / acetone / 20 °C

5.1: 69 percent / aq. NaIO₄ / 2-methyl-propan-2-ol / 20 °C

6.1: CHCl₃

7.1: CHCl₃ / 10 h / 0 - 20 °C

8.1: 81 percent / HCl / diethyl ether / 48 h / 0 - 20 °C

9.1: Pb(OAc)4 / CH₂Cl₂; methanol / 0.25 h

9.2: H₂ / 20percent Pd(OH)2/C / ethanol / 2585.81 Torr

10.1: Et₃N / tetrahydrofuran / 20 °C

With lead(IV) acetate; hydrogenchloride; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; acetone; toluene; tert-butyl alcohol;
DOI:10.1039/b008970m

Reference yield:

: 37439-78-4
N-(3-(allyloxy)phenyl)acetamide

: 340774-82-5
2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: PhNMe₂ / 6 h / Heating

2.1: 82 percent / K₂CO₃ / acetone / Heating

3.1: 81 percent / HCl / 2 h / Heating

4.1: 72 percent / toluene / 24 h / Heating

5.1: 74 percent / OsO₄; NMO / acetone / 20 °C

6.1: 69 percent / aq. NaIO₄ / 2-methyl-propan-2-ol / 20 °C

7.1: CHCl₃

8.1: CHCl₃ / 10 h / 0 - 20 °C

9.1: 81 percent / HCl / diethyl ether / 48 h / 0 - 20 °C

10.1: Pb(OAc)4 / CH₂Cl₂; methanol / 0.25 h

10.2: H₂ / 20percent Pd(OH)2/C / ethanol / 2585.81 Torr

11.1: Et₃N / tetrahydrofuran / 20 °C

With lead(IV) acetate; hydrogenchloride; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; potassium carbonate; N,N-dimethyl-aniline; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; acetone; toluene; tert-butyl alcohol; 1.1: Claisen rearrangement;
DOI:10.1039/b008970m