(2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

Base Information

Chemical Name:(2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine
CAS No.:1273549-60-2
Molecular Formula:C₂₀H₂₁BrN₄O₂
Molecular Weight:429.316
Hs Code.:

Synonyms:(2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

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Chemical Property of (2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

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Technology Process of (2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

There total 9 articles about (2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1273550-58-5
[6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

: 1273549-60-2
(2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

Guidance literature:: With 1,2-dibromo-1,1,2,2-tetrachloroethane; tributylphosphine; triethylamine; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 101584-93-4,888298-05-3
benzyl-(3-hydroxy-1-phenylpropyl)carbamate

: 1273549-60-2
(2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -50 °C

1.2: 0.58 h / -50 - 20 °C

2.1: triethylamine; lithium chloride / acetonitrile / 18 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 65 °C / 2327.23 Torr

4.1: methyl trifluoromethanesulfonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.2: 3.5 h / 0 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 18 h / 20 °C

6.1: triethylamine; tributylphosphine; 1,2-dibromo-1,1,2,2-tetrachloroethane / 1.5 h / 0 - 20 °C

With oxalyl dichloride; 1,2-dibromo-1,1,2,2-tetrachloroethane; tributylphosphine; hydrogen; dimethyl sulfoxide; triethylamine; methyl trifluoromethanesulfonate; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 14593-04-5,82769-76-4
3-amino-3-phenyl-1-propanol

: 1273549-60-2
(2-bromo-4,5-dimethoxy-phenyl)-(5-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / ethyl acetate; water / 2 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -50 °C

2.2: 0.58 h / -50 - 20 °C

3.1: triethylamine; lithium chloride / acetonitrile / 18 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 65 °C / 2327.23 Torr

5.1: methyl trifluoromethanesulfonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5.2: 3.5 h / 0 - 20 °C / Inert atmosphere

6.1: tetrahydrofuran / 18 h / 20 °C

7.1: triethylamine; tributylphosphine; 1,2-dibromo-1,1,2,2-tetrachloroethane / 1.5 h / 0 - 20 °C

With oxalyl dichloride; 1,2-dibromo-1,1,2,2-tetrachloroethane; tributylphosphine; hydrogen; sodium carbonate; dimethyl sulfoxide; triethylamine; methyl trifluoromethanesulfonate; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;