[6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

Base Information

Chemical Name:[6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone
CAS No.:1273550-58-5
Molecular Formula:C₂₀H₂₃BrN₄O₃
Molecular Weight:447.332
Hs Code.:

Synonyms:[6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

Chemical Property:

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Technology Process of [6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

There total 8 articles about [6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1232688-41-3
1-bromo-2-isocyanato-4,5-dimethoxybenzene

: 1273550-41-6
[6-phenyl-piperidin-(2Z)-ylidene]-hydrazine

: 1273550-58-5
[6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 101584-93-4,888298-05-3
benzyl-(3-hydroxy-1-phenylpropyl)carbamate

: 1273550-58-5
[6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -50 °C

1.2: 0.58 h / -50 - 20 °C

2.1: triethylamine; lithium chloride / acetonitrile / 18 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 65 °C / 2327.23 Torr

4.1: methyl trifluoromethanesulfonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.2: 3.5 h / 0 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 18 h / 20 °C

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; methyl trifluoromethanesulfonate; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 14593-04-5,82769-76-4
3-amino-3-phenyl-1-propanol

: 1273550-58-5
[6-phenyl-piperidin-(2Z)-ylidene]-2-bromo-4,5-dimethoxy-phenyl semicarbazone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / ethyl acetate; water / 2 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -50 °C

2.2: 0.58 h / -50 - 20 °C

3.1: triethylamine; lithium chloride / acetonitrile / 18 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 65 °C / 2327.23 Torr

5.1: methyl trifluoromethanesulfonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5.2: 3.5 h / 0 - 20 °C / Inert atmosphere

6.1: tetrahydrofuran / 18 h / 20 °C

With oxalyl dichloride; hydrogen; sodium carbonate; dimethyl sulfoxide; triethylamine; methyl trifluoromethanesulfonate; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;