7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

Base Information

Chemical Name:7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid
CAS No.:72851-48-0
Molecular Formula:C₁₄H₈F₃N₃O₂
Molecular Weight:307.232
Hs Code.:

Synonyms:7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

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Chemical Property of 7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

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Technology Process of 7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

There total 5 articles about 7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 72851-46-8
7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

: 72851-48-0
7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 4h; Heating;
DOI:10.1016/0223-5234(94)90065-5

Reference yield:

: 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

: 72851-48-0
7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

Guidance literature:: With hydrogenchloride; In dichloromethane;

Reference yield:

: 72851-19-5
(E)-3-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one

: 72851-48-0
7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / AcOH / 8 h / Heating

2: 52 percent / 6 N aq. NaOH / ethanol / 4 h / Heating

With sodium hydroxide; acetic acid; In ethanol;
DOI:10.1016/0223-5234(94)90065-5