4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine

Base Information

• Chemical Name: 4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine
• CAS No.: 52601-52-2
• Molecular Formula: C₂₆H₁₉NOS
• Molecular Weight: 393.509
• Mol file: 52601-52-2.mol

Synonyms:4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine

Chemical Property of 4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine

There total 5 articles about 4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

1-{2-(naphthalen-2-yl)-2-oxoethyl}pyridinium iodide (6277-72-1) + (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one (6028-93-9) → 4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine (52601-52-2)

Guidance literature:

1-{2-(naphthalen-2-yl)-2-oxoethyl}pyridinium iodide; With ammonium acetate; acetic acid; at 130 ℃; for 0.166667h;

(2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one; for 18h; Reflux;

DOI:10.1002/ejic.201700792

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine (52601-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol; water / 20 °C

2.1: ammonium acetate; acetic acid / 0.17 h / 130 °C

2.2: 18 h / Reflux

With ammonium acetate; acetic acid; potassium hydroxide; In ethanol; water; 2.1: |Kroehnke Pyridine Synthesis / 2.2: |Kroehnke Pyridine Synthesis;

DOI:10.1002/ejic.201700792

Reference yield:

pyridine (110-86-1) → 4-(4'-methoxyphenyl)-2-(naphthalen-2-yl)-6-(thiophen-2-yl)pyridine (52601-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine / 2 h / 120 °C

2.1: ammonium acetate; acetic acid / 0.17 h / 130 °C

2.2: 18 h / Reflux

With ammonium acetate; iodine; acetic acid; 2.1: |Kroehnke Pyridine Synthesis / 2.2: |Kroehnke Pyridine Synthesis;

DOI:10.1002/ejic.201700792

upstream raw materials:

pyridine

methyl 2-naphthyl ketone

4-methoxy-benzaldehyde

1-{2-(naphthalen-2-yl)-2-oxoethyl}pyridinium iodide