N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

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Chemical Name:N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide
CAS No.:1625677-45-3
Molecular Formula:C₂₉H₃₀FN₇O₃
Molecular Weight:543.601
Hs Code.:

Synonyms:N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

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Chemical Property of N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

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Technology Process of N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

There total 10 articles about N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1375465-27-2
N₁-(1-(2-fluoroethyl)azetidin-3-yl)-3-methoxybenzene-1,4-diamine

: 1625678-21-8
N-(3-(5-methyl-2-(methylsulfinyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

: 1625677-45-3
N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tert-butyl alcohol; at 80 ℃; for 1h;

Reference yield:

: 1363161-16-3
tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 1625677-45-3
N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran; diethyl ether / 2.08 h / 0.5 - 8 °C / Inert atmosphere

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

3.2: 3 h / -78 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.42 h / 0 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

7.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 1 h / 80 °C

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl alcohol;

Reference yield:

: 1584151-18-7
tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

: 1625677-45-3
N-(3-(2-((4-((1-(2-fluoroethyl)-3-azetidinyl)amino)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

1.2: 3 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.42 h / 0 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 1 h / 80 °C

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;