1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide

Base Information

Chemical Name:1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide
CAS No.:1207202-94-5
Molecular Formula:C₃₃H₃₂Cl₂N₂O₃S₂
Molecular Weight:639.667
Hs Code.:

Synonyms:1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide

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Chemical Property of 1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide

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Technology Process of 1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide

There total 4 articles about 1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56243-25-5
1-benzyl-4-cyano-4-phenylpiperidine

: 1207202-94-5
1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sulfuric acid / 1 h / 100 °C

1.2: Cooling with ice

2.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

4.1: sodium hydride / xylene / 1.25 h / 0 °C / Inert atmosphere

4.2: 150 °C

With sulfuric acid; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; xylene;

Reference yield:

: 14970-83-3
4-Mercapto-1-butanol

: 1207203-52-8
1-{[4-(4-bromophenyl)-5-(2,4-dichlorophenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

: 1207202-94-5
1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide

Guidance literature:: 4-Mercapto-1-butanol; With sodium hydride; In xylene; at 0 ℃; for 1.25h; Inert atmosphere;

1-{[4-(4-bromophenyl)-5-(2,4-dichlorophenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In xylene; at 150 ℃;

Reference yield:

: 59084-07-0
1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide; hydrochloride

: 1207202-94-5
1-[[5-(2,4-dichlorophenyl)-4-[4-[(4-hydroxybutyl)thio]phenyl]-2-thienyl]carbonyl]-4-phenyl-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

3.1: sodium hydride / xylene / 1.25 h / 0 °C / Inert atmosphere

3.2: 150 °C

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; xylene;