1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt

Base Information

• Chemical Name: 1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt
• CAS No.: 1403232-67-6
• Molecular Formula: C₄H₁₁N*C₂₉H₂₈ClN₃O₃
• Molecular Weight: 575.151
• Mol file: 1403232-67-6.mol

Synonyms:1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt

Chemical Property of 1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt

There total 6 articles about 1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-ethylpiperidine-4-carboxylic acid (1227465-48-6) + 4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde (1403234-06-9) + tert-butylamine (75-64-9) → 1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt (1403232-67-6)

Guidance literature:

4-ethylpiperidine-4-carboxylic acid; 4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde; With acetic acid; In methanol; dichloromethane; water; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; dichloromethane; water; at 20 ℃; for 1.5h;

tert-butylamine; In methanol; dichloromethane;

Reference yield:

2-chloro-4-bromoaniline (38762-41-3) → 1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt (1403232-67-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper dichloride; nitrous acid isobutyl ester / 2 h / 60 - 65 °C / Reflux

1.2: 1 h / 50 - 55 °C / Reflux

2.1: hydrogenchloride; iodine; magnesium; carbon dioxide / tetrahydrofuran / 1 h / 60 - 70 °C / Reflux

2.2: 0.75 h / -20 °C

3.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 3 h / 120 - 125 °C

4.1: pyridinium chlorochromate / dichloromethane / 0.5 h / 20 °C

5.1: acetic acid / dichloromethane; water; methanol / 0.5 h / 20 °C

5.2: 1.5 h / 20 °C

With hydrogenchloride; nitrous acid isobutyl ester; carbon dioxide; iodine; magnesium; acetic acid; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; pyridinium chlorochromate; copper dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1-{4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-ethylpiperidine-4-carboxylic acid tert-butyl amine salt (1403232-67-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper dichloride; nitrous acid isobutyl ester / 2 h / 60 - 65 °C / Reflux

1.2: 1 h / 50 - 55 °C / Reflux

2.1: hydrogenchloride; iodine; magnesium; carbon dioxide / tetrahydrofuran / 1 h / 60 - 70 °C / Reflux

2.2: 0.75 h / -20 °C

3.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 3 h / 120 - 125 °C

4.1: pyridinium chlorochromate / dichloromethane / 0.5 h / 20 °C

5.1: acetic acid / dichloromethane; water; methanol / 0.5 h / 20 °C

5.2: 1.5 h / 20 °C

With hydrogenchloride; nitrous acid isobutyl ester; carbon dioxide; iodine; magnesium; acetic acid; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; pyridinium chlorochromate; copper dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

benzene

4-ethylpiperidine-4-carboxylic acid

4-[5-(2-chlorobiphenyl-4-yl)-[1,2,4]-oxadiazol-3-yl]-benzaldehyde

tert-butylamine