Technology Process of 4-ethyl-4-piperidinecarboxylic acid(SALTDATA: 0.95HCl 0.07dioxane)
There total 4 articles about 4-ethyl-4-piperidinecarboxylic acid(SALTDATA: 0.95HCl 0.07dioxane) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 6h;
With
sodium hydrogencarbonate;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.17 h / 0 - 20 °C
1.2: 14 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1.25 h / -75 - -35 °C / Inert atmosphere
2.2: 12 h / -75 - 20 °C / Inert atmosphere
3.1: potassium hydroxide; ethanol / 16 h / Reflux
4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C
With
n-butyllithium; ethanol; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1.25 h / -75 - -35 °C / Inert atmosphere
1.2: 12 h / -75 - 20 °C / Inert atmosphere
2.1: potassium hydroxide; ethanol / 16 h / Reflux
3.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C
With
n-butyllithium; ethanol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; dichloromethane;
