4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde

Base Information

• Chemical Name: 4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde
• CAS No.: 151416-78-3
• Molecular Formula: C₃₃H₄₁N₅O₁₀
• Molecular Weight: 667.716
• Mol file: 151416-78-3.mol

Synonyms:4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde

Chemical Property of 4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde

There total 1 articles about 4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.7%

4-tri-n-butylstannylbenzaldehyde (88373-27-7) + 8-bromo-2-i-butyramido-9-(2',3',5'-tri-O-i-butyryl-β-D-ribofuranosyl)-1H-purine-6-one (151416-77-2) → 4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde (151416-78-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 38h; Heating;

DOI:10.1021/ja00107a014

Reference yield: 91.0%

ethyl acetoacetate (141-97-9) + urea (57-13-6) + 4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde (151416-78-3) → 4-{4-[9-((2R,3R,4R,5R)-3,4-Bis-isobutyryloxy-5-isobutyryloxymethyl-tetrahydro-furan-2-yl)-2-isobutyrylamino-6-oxo-6,9-dihydro-1H-purin-8-yl]-phenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:

With sulphated SnO₂; In toluene; for 1h; Heating;

Reference yield:

bis(3-butyl-4-methyl-2-pyrrolyl)methane (116748-68-6) + benzaldehyde (100-52-7) + 4-<2-isobutyramido-9-(2,3,5-tri-O-isobutyryl-β-D-ribofuranosyl)purin-6-on-8-yl>benzaldehyde (151416-78-3) → C78H97N9O9

Guidance literature:

With chloranil; trifluoroacetic acid; Yield given. Multistep reaction; 1.) CH₂Cl₂;

DOI:10.1021/ja00075a091

upstream raw materials:

4-tri-n-butylstannylbenzaldehyde

8-bromo-2-i-butyramido-9-(2',3',5'-tri-O-i-butyryl-β-D-ribofuranosyl)-1H-purine-6-one

Downstream raw materials:

5,15-diphenyl-3,7,13,17-tetramethyl-2,8,12,18-tetrabutylporphyrin