Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

Base Information

Chemical Name:Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester
CAS No.:132507-77-8
Molecular Formula:C₁₄H₁₂F₅N₃O₃
Molecular Weight:365.26
Hs Code.:

Synonyms:Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

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Technology Process of Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

There total 8 articles about Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126918-20-5,132563-67-8,138457-41-7
(2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,2,3-butanetriol

: 132507-77-8
Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / pyridine / 0.5 h / 0 °C

2: dimethylformamide / 2 h / 65 - 70 °C

3: 6 h / 0 °C

With pyridine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2476

Reference yield:

: 132563-81-6
1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one

: 132507-77-8
Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether; tetrahydrofuran / 0.17 h / Ambient temperature

2: NaHCO₃, 35percent H₂O₂ / tetrahydrofuran; methanol / 1.5 h / 70 °C

3: p-toluenesulfonic acid / methanol / 0.5 h / Ambient temperature

4: 96 percent / pyridine / 0.5 h / 0 °C

5: dimethylformamide / 2 h / 65 - 70 °C

6: 6 h / 0 °C

With pyridine; dihydrogen peroxide; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2476

Reference yield:

: 126918-19-2,132563-82-7
(2S,3S)-2-(2,4-Difluoro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-butane-1,2-diol

: 132507-77-8
Trifluoro-acetic acid (1R,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / methanol / 0.5 h / Ambient temperature

2: 96 percent / pyridine / 0.5 h / 0 °C

3: dimethylformamide / 2 h / 65 - 70 °C

4: 6 h / 0 °C

With pyridine; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2476