ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate

Base Information

Chemical Name:ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate
CAS No.:334015-59-7
Molecular Formula:C₂₃H₂₆F₃NO₄
Molecular Weight:437.459
Hs Code.:

Synonyms:ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate

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Chemical Property of ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate

Chemical Property:

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Technology Process of ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate

There total 11 articles about ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 2942-58-7
diethyl cyanophosphonate

: 378231-96-0
2-[5-(2-ethoxycarbonyl)butyl-2-methoxyphenyl]acetic Acid

: 334015-59-7
ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate

Guidance literature:: With triethylamine; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl-formamide;

Reference yield:

: 17145-91-4
triethyl 2-ethylphosphonoacetate

: 334015-59-7
ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 1 h

1.2: tetrahydrofuran / 4 h / 0 - 20 °C

2.1: 97 percent / Zn; AcOH / 6 h / 20 °C

3.1: H₂ / Pd/C / ethanol / 3 h / 2647.71 Torr

4.1: Et₃N / CH₂Cl₂ / 0.17 h / -10 °C

5.1: CH₂Cl₂ / -10 - 20 °C

With hydrogen; sodium hydride; acetic acid; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm0205144

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 334015-59-7
ethyl 2-ethyl-3-[4-methoxy-3-[[N-[4-(trifluoromethyl)phenyl]carbamoyl]methyl]phenyl]propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: TiCl₃ / CH₂Cl₂ / 0.25 h / 20 °C

1.2: 52 percent / CH₂Cl₂; CCl₄ / 24 h / Heating

2.1: aq. NaOH / ethanol / 3 h / 20 °C

3.1: 76 percent / K₂CO₃ / dimethylformamide / 5 h / 20 °C

4.1: NaH / tetrahydrofuran / 1 h

4.2: tetrahydrofuran / 4 h / 0 - 20 °C

5.1: 97 percent / Zn; AcOH / 6 h / 20 °C

6.1: H₂ / Pd/C / ethanol / 3 h / 2647.71 Torr

7.1: Et₃N / CH₂Cl₂ / 0.17 h / -10 °C

8.1: CH₂Cl₂ / -10 - 20 °C

With sodium hydroxide; titanium(III) chloride; hydrogen; sodium hydride; potassium carbonate; acetic acid; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205144