Chemical Property of (S)-Piperazine-2-carboxylic acid
Chemical Property:
- Appearance/Colour:yellow powder
- Vapor Pressure:0.000107mmHg at 25°C
- Melting Point:243-247 °C (dec.)
- Refractive Index:1.476
- Boiling Point:313.6 °C at 760 mmHg
- PKA:1.90±0.20(Predicted)
- Flash Point:143.5 °C
- PSA：61.36000
- Density:1.174 g/cm3
- LogP:-0.71000
- XLogP3:-3.5
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:130.074227566
- Heavy Atom Count:9
- Complexity:116
- Purity/Quality:
-
99% *data from raw suppliers
(S)-Piperazine-2-carboxylicacid *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CNC(CN1)C(=O)O
- Isomeric SMILES:C1CN[C@@H](CN1)C(=O)O
-
General Description
(S)-Piperazine-2-carboxylic acid can be efficiently synthesized via continuous resolution using (S)-camphor-10-sulfonic acid as a resolving agent, yielding the product in high enantiomeric excess (>99% ee) and moderate isolated yield (62%). This method demonstrates a practical approach for obtaining the (S)-enantiomer of piperazine-2-carboxylic acid through diastereomeric salt formation and epimerization.
