(S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Base Information

Chemical Name:(S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate
CAS No.:1417718-78-5
Molecular Formula:C₂₃H₃₁NO₃S
Molecular Weight:401.57
Hs Code.:

Synonyms:(S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Suppliers and Price of (S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

There total 10 articles about (S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1417718-77-4
methyl 5-(3,3-dimethylbut-1-ynyl)-3-(isopropylamino)thiophene-2-carboxylate

: 170080-85-0
(S)-4-methyl-3-cyclohexene-1-carbonyl chloride

: 1417718-78-5
(S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Guidance literature:: In aq. phosphate buffer; dichloromethane; at 90 ℃; for 16h; Sealed tube;

Reference yield: 51.0%

: 1417718-77-4
methyl 5-(3,3-dimethylbut-1-ynyl)-3-(isopropylamino)thiophene-2-carboxylate

: 121424-36-0
(+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid

: 1417718-78-5
(S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Guidance literature:: With potassium phosphate; In dichloromethane; at 90 ℃; for 16h; Sealed tube;
DOI:10.1021/jm401420j

Reference yield:

: 1026785-75-0
methyl 3-amino-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylate

: 1417718-78-5
(S)-methyl 5-(3,3-dimethylbut-1-ynyl)-3-(N-isopropyl-4-methylcyclohex-3-enecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 - 20 °C

2: dichloromethane; aq. phosphate buffer / 16 h / 90 °C / Sealed tube

With sodium tris(acetoxy)borohydride; acetic acid; In aq. phosphate buffer; dichloromethane;