121424-36-0Relevant articles and documents
Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase
Loizzi, Marianna,Miller, David J.,Allemann, Rudolf K.
, p. 1206 - 1214 (2019/02/07)
δ-Cadinene synthase (DCS) is a high-fidelity sesquiterpene synthase that generates δ-cadinene as the sole detectable organic product from its natural substrate (E,E)-FDP. Previous work with this enzyme using substrate analogues revealed the ability of DCS
Synthesis of a Chiral Auxiliary Family from Levoglucosenone and Evaluation in the Diels-Alder Reaction
Klepp, Julian,Sumby, Christopher J.,Greatrex, Ben W.
supporting information, p. 1441 - 1446 (2018/06/08)
A new family of chiral auxiliaries has been developed based on the lignocellulosic biomass pyrolysis product levoglucosenone. A promising single stereoisomer with an alcohol and π-stacking phenyl substituents was prepared in excellent yield in two steps from dihydrolevoglucosenone without chromatography on >50 g scale. Acrylate esters prepared from the auxiliaries underwent diastereoselective Lewis acid promoted Diels-Alder reactions with cyclopentadiene (endo / exo 98:2, endo d. r. up to 98:2), dimethylbutadiene (d.r. 93:7), and isoprene (d.r. > 98:2).
SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE
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Paragraph 0651; 0652, (2015/08/04)
Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE
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Paragraph 00453, (2015/11/02)
Provided herein are formulations, processes, solid forms and methods of use relating to 2- (tert-butylamino)-4-((lR,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5- carboxamide.
SYNTHESIS OF AN ANTIVIRAL COMPOUND
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Paragraph 0188; 0189, (2014/03/22)
The present disclosure provides processes for the preparation of a compound of Formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula.
SYNTHESIS OF AN ANTIVIRAL COMPOUND
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Paragraph 0139, (2014/03/22)
The present disclosure provides a processes for the preparation of a compound of Formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of Formula I.
METHODS FOR TREATING HCV
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Page/Page column 81-82, (2013/03/28)
This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.
METHODS FOR TREATING HCV
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Paragraph 0324, (2013/10/22)
This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.
THIOPHEN-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS INHIBITORS OF FLAVIVIRIDAE VIRUSES
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Page/Page column 35; 36; 38, (2013/03/26)
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections (e.g. hepatitis C infections), particularly drug
Second generation levoglucosenone-derived chiral auxiliaries. Scope and application in asymmetric Diels-Alder reactions
Sarotti, Ariel M.,Spanevello, Rolando A.,Suárez, Alejandra G.
supporting information; experimental part, p. 3502 - 3508 (2009/08/15)
Chiral alcohols were designed and easily prepared from levoglucosenone, a biomass-derived valuable synthon. These alcohols were tested as chiral auxiliaries in asymmetric Diels-Alder reactions between the corresponding acrylates with acyclic and cyclic di