(+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid

Base Information

• Chemical Name: (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid
• CAS No.: 121424-36-0
• Molecular Formula: C8H12O2
• Molecular Weight: 140.182
• Mol file: 121424-36-0.mol

Synonyms:.(1R)-4-methylcyclohex-3-enecarboxylic acid;.(R)-4-methyl-3-cyclohexene-1-carboxylic acid;.(R)-4-methylcyclohex-3-enecarboxylic acid;.4-methyl-3-cyclohexene-1-carboxylic acid;.(R)-4-methylcyclohex-3-ene carboxylic acid;(1R)-4-methyl-cyclohex-3-enecarboxylic acid;

Chemical Property of (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid

Chemical Property:

• Melting Point: 92-94 °C
• Boiling Point: 251.4±19.0 °C(Predicted)
• PKA: 4.68±0.40(Predicted)
• PSA: 37.30000
• Density: 1.078±0.06 g/cm3(Predicted)
• LogP: 1.81740

Purity/Quality:

97% ^*data from raw suppliers

(+)-(1R)-4-methyl-cyclohex-3-enecarboxylicacid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid

There total 25 articles about (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1S,4S,5R)-3,3-dibenzyl-6,8-dioxabicyclo[3.2.1]octan-4-yl (R)-4-methylcyclohex-3-ene-1-carboxylate → (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid (121424-36-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 144h;

DOI:10.1055/s-0037-1610148

Reference yield: 90.0%

(4S,1'R)-3-[(4'-methylcyclohex-3'-ene-1'-yl)carbonyl]-4-iso-propyloxazolidin-2-one (90719-40-7) → (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid (121424-36-0)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1039/b605346g

Reference yield: 80.0%

(1R)-4-methyl-cyclohex-3-enecarboxylic acid 2,2,2-trifluoro-ethyl ester → (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid (121424-36-0)

Guidance literature:

With water; lithium hydroxide; In methanol;

upstream raw materials:

(1R,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-methylcyclohex-3-enecarboxylate

Acrylic acid (1R,5S,6S)-6-(2,2-dimethyl-propionylamino)-spiro[4.4]non-1-yl ester

isoprene

(R)-4-Methyl-cyclohex-3-enecarboxylic acid (1R,5R,6R)-6-(2,2-dimethyl-propionylamino)-spiro[4.4]non-1-yl ester

Downstream raw materials:

(1R)-4-methylcyclohex-3-enecarboxylic acid chloride

5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

5-(3,3-dimethyl-but-1-ynyl)-3-[((1R)-4-methyl-cyclohex-3-enecarbonyl)-(4-oxo-cyclohexyl)-amino]-thiophene-2-carboxylic acid methyl ester

(R)-N-(5-(3,3-dimethylbut-1-yn-1-yl)thiophen-3-yl)-4-methyl-N-(4-oxocyclohexyl)cyclohex-3-enecarboxamide