methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate

Base Information

Chemical Name:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate
CAS No.:1383786-57-9
Molecular Formula:C₁₉H₁₈ClNO₆
Molecular Weight:391.808
Hs Code.:

Synonyms:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate

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Chemical Property of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate

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Technology Process of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate

There total 6 articles about methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 622-33-3
N-benzyloxyamine

: 1383786-56-8
methyl 5-chloro-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

: 1383786-57-9
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate

Guidance literature:: In toluene; Reflux; Dean-Stark;
DOI:10.1021/jm500109z

Reference yield: 35.0%

: 1383786-57-9
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate

Guidance literature:

Reference yield:

: 2965-22-2
methyl 2-fluoro-5-nitro-benzoate

: 1383786-57-9
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-chlorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / Inert atmosphere; Reflux

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 - 5 °C

3.2: 12 h / Heating

4.1: toluene / Reflux; Dean-Stark

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; sodium hydride; sodium nitrite; In tetrahydrofuran; methanol; water; toluene; mineral oil;
DOI:10.1021/jm500109z