H-DL-PRO-OME HCL

Base Information

• Chemical Name: H-DL-PRO-OME HCL
• CAS No.: 79397-50-5
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.62
• Hs Code.: 2933990090
• Mol file: 79397-50-5.mol

Synonyms:DL-Proline,methyl ester, hydrochloride; Proline, methyl ester, hydrochloride (9CI); Methylpyrrolidine-2-carboxylate hydrochloride; Pyrrolidine-2-carboxylic acid methylester hydrochloride

Chemical Property of H-DL-PRO-OME HCL

Chemical Property:

• Melting Point: 239-241 °C
• PSA: 38.33000
• LogP: 1.04220
• Storage Temp.: -15°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

DL-Proline methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl Pyrrolidine-2-carboxylate Hydrochloride (cas# 79397-50-5) is a compound useful in organic synthesis.

Technology Process of H-DL-PRO-OME HCL

There total 6 articles about H-DL-PRO-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → methyl pyrrolidine-2-carboxylate hydrochloride (2133-40-6,65365-28-8,79397-50-5)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 20h;

DOI:10.1002/chem.202005351

Reference yield: 88.0%

(+/-)-N-tert-butoxycarbonylproline methyl ester (145681-01-2) → methyl pyrrolidine-2-carboxylate hydrochloride (2133-40-6,65365-28-8,79397-50-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 5h;

Reference yield:

rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → methyl pyrrolidine-2-carboxylate hydrochloride (2133-40-6,65365-28-8,79397-50-5)

Guidance literature:

With thionyl chloride; In methanol;

upstream raw materials:

methanol

rac-Pro-OH

N-tert-butoxycarbonyl-proline

L-proline

Downstream raw materials:

(3R,8aS)-3-phenyl-3-(2-propenyl)-1,4-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo<2,1-c><1,4>oxazine

methyl (2S,1'S)-N-<(1-hydroxy-1-phenyl-3-butenyl)-formyl>prolinate

N-[(Phenylmethoxy)carbonyl]-L-valyl-L-proline methyl ester

1-benzylpyrrolidine-2-carboxylic acid methyl ester

Refernces

• 1、 -. "COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING". Paragraph 0854-0857. . Retrieved 2021/08/06.
• 2、 Rodionov,Snegur,Simenel,Dobryakova, Yu. V.,Markevich. "Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus". . p. 136 - 142. Retrieved 2017/07/05.