Methyl 2-(4-nitrophenyl)-2-oxoacetate

Base Information

• Chemical Name: Methyl 2-(4-nitrophenyl)-2-oxoacetate
• CAS No.: 57699-27-1
• Molecular Formula: C₉H₇NO₅
• Molecular Weight: 209.158
• Mol file: 57699-27-1.mol

Synonyms:methyl p-nitrophenylglyoxylate

Chemical Property of Methyl 2-(4-nitrophenyl)-2-oxoacetate

Chemical Property:

• Melting Point: 105 °C(Solv: methanol (67-56-1); water (7732-18-5))
• Boiling Point: 354.1±25.0 °C(Predicted)
• Density: 1.368±0.06 g/cm3(Predicted)

Purity/Quality:

90% ^*data from raw suppliers

Methyl2-(4-nitrophenyl)-2-oxoacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: Methyl 2-(4-nitrophenyl)-2-oxoacetate, a chemical compound, has applications in various fields. In the field of organic synthesis and pharmaceuticals, it serves as a valuable intermediate for the synthesis of complex organic molecules and pharmaceutical compounds. Its role is pivotal in the development of specialty chemicals and medications for a wide range of medical conditions. Additionally, in the realm of chemical research and analytical chemistry, this compound can be utilized as a reference compound for the study of nitrophenyl derivatives and their reactivity, contributing to the advancement of synthetic methodologies and chemical understanding. Its multifaceted utility underscores its significance in advancing pharmaceutical research, chemical synthesis, and scientific investigation, where it plays a crucial role in drug discovery, chemical processes, and compound analysis.

Technology Process of Methyl 2-(4-nitrophenyl)-2-oxoacetate

There total 15 articles about Methyl 2-(4-nitrophenyl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl (±)-2-hydroxy-2-(4-nitrophenyl)acetate (13305-09-4) → methyl p-nitrophenylglyoxylate (57699-27-1)

Guidance literature:

With lead(IV) acetate; In acetic acid; benzene; at 35 ℃; Rate constant; Mechanism;

Reference yield: 83.0%

4-nitrophenylglyoxal (4974-57-6) + methyl bromide (74-83-9) → methyl p-nitrophenylglyoxylate (57699-27-1)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; at 60 ℃; for 2h; Sealed tube;

DOI:10.1080/00397911.2019.1600193

Reference yield: 65.0%

methyl 2-diazo-2-(4-nitrophenyl)acetate (22812-58-4) → methyl p-nitrophenylglyoxylate (57699-27-1)

Guidance literature:

With water; diethylazodicarboxylate; dirhodium tetraacetate; In toluene; for 4h; Heating;

DOI:10.1055/s-2006-950412

upstream raw materials:

diazomethane

4-nitrophenylglyoxylic acid

methyl (4-nitrophenyl)acetate

methyl (±)-2-hydroxy-2-(4-nitrophenyl)acetate

Downstream raw materials:

cis-2,3-bis(carbomethoxy)-p,p'-dinitrostilbene oxide

trans-2,3-bis(carbomethoxy)-p,p'-dinitrostilbene oxide

Methyl (S)-2-hydroxy-2-(4-nitrophenyl)acetate

methyl (±)-2-hydroxy-2-(4-nitrophenyl)acetate