ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate

Base Information

Chemical Name:ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate
CAS No.:1045601-10-2
Molecular Formula:C₃₀H₄₄FN₃O₆SSi
Molecular Weight:621.846
Hs Code.:

Synonyms:ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate

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Chemical Property of ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate

There total 2 articles about ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: imidazolyl (4E)-5-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(3S)-3-(t-butyldimethylsilyloxy)pentenoate

: 1045601-10-2
ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate

Guidance literature:: hydrogen ethyl malonate; With ethanol; diethylzinc; In toluene; at 10 - 30 ℃; for 18h;

imidazolyl (4E)-5-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(3S)-3-(t-butyldimethylsilyloxy)pentenoate; In toluene; at 20 ℃; for 40h;

With water; citric acid; In toluene; Product distribution / selectivity;

Reference yield:

: 1045601-11-3
(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-(3S)-3-(O-tert-butyldimethylsilyl)-4-pentenoic acid

: 37517-78-5
magnesium bis(3-ethoxy-3-oxopropanoate)

: 1045601-10-2
ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate

Guidance literature:: (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-(3S)-3-(O-tert-butyldimethylsilyl)-4-pentenoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran;

magnesium bis(3-ethoxy-3-oxopropanoate); In tetrahydrofuran; for 20h;

With sodium carbonate; In water; ethyl acetate; toluene; Product distribution / selectivity;

Reference yield: 66.0%

: 1045601-10-2
ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate

: 901765-36-4
(S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxy-3-oxohept-6-enoate

Guidance literature:: ethyl 6-(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-methylsulfonylamino]pyrimidin-5-yl]-(5S)-5-(t-butyldimethylsilyloxy)-3-oxoheptenoate; With hydrogen fluoride; In water; acetonitrile; at 0 - 30 ℃; for 0.333333 - 2.25h;

With sodium hydrogencarbonate; In water; acetonitrile; Product distribution / selectivity;