O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite

Base Information

Chemical Name:O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite
CAS No.:228406-23-3
Molecular Formula:C₅₀H₉₂NO₆P
Molecular Weight:834.257
Hs Code.:

Synonyms:O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite

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Chemical Property of O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite

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Technology Process of O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite

There total 5 articles about O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 90932-89-1
(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl octadecanoate

: 228406-23-3
O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4020(00)00161-7

Reference yield:

: 4145-51-1,6236-22-2,116947-35-4,988-76-1
3-O-Benzyl-1-O-octadecanoyl-sn-glycerin

: 228406-23-3
O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / N,N-dimethylaminopyridine / pyridine; CH₂Cl₂ / 0 - 20 °C

2: 67 percent / H₂ / Pd/C / ethyl acetate / 20 °C

3: 86 percent / 1H-tetrazole / CH₂Cl₂ / 20 °C

With 1H-tetrazole; dmap; hydrogen; palladium on activated charcoal; In pyridine; dichloromethane; ethyl acetate; 1: Acylation / 2: Hydrogenolysis / 3: Substitution;
DOI:10.1016/S0040-4020(00)00161-7

Reference yield:

: 282532-76-7
3-O-benzyl-2-O-hexadecanoyl-1-O-octadecanoyl-sn-glycerol

: 228406-23-3
O-benzyl O-(2R)-2-hexadecanoyloxy-3-octadecanoyloxypropyl-N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / H₂ / Pd/C / ethyl acetate / 20 °C

2: 86 percent / 1H-tetrazole / CH₂Cl₂ / 20 °C

With 1H-tetrazole; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate; 1: Hydrogenolysis / 2: Substitution;
DOI:10.1016/S0040-4020(00)00161-7