(S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate

Base Information

• Chemical Name: (S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate
• CAS No.: 1448616-12-3
• Molecular Formula: C₂₀H₃₂N₂O₄
• Molecular Weight: 364.485
• Mol file: 1448616-12-3.mol

Synonyms:(S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate

Chemical Property of (S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate

There total 1 articles about (S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

L-leucine tert-butyl ester (21691-53-2) + 3-(dimethylamino)phenoxyacetic acid (150188-64-0) → (S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate (1448616-12-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.08333h;

DOI:10.1016/j.ejmech.2013.05.005

Reference yield:

(S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate (1448616-12-3) → C16H24N2O4 (1234189-96-8)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1.08333h;

DOI:10.1016/j.ejmech.2013.05.005

Reference yield:

(S)-tert-butyl 2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanoate (1448616-12-3) → (S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanamide (1448616-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: / dichloromethane / 1.08 h / 0 - 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.05.005

upstream raw materials:

L-leucine tert-butyl ester

3-(dimethylamino)phenoxyacetic acid

Downstream raw materials:

C₁₆H₂₄N₂O₄

(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(2-(3-(dimethylamino)phenoxy)acetamido)-4-methylpentanamide