3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

Base Information

Chemical Name:3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol
CAS No.:704912-92-5
Molecular Formula:C₃₂H₅₂Cl₂O₆Si₂
Molecular Weight:659.838
Hs Code.:

Synonyms:3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

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Chemical Property of 3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

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Technology Process of 3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

There total 9 articles about 3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 704913-01-9
C₃₂H₅₁BrCl₂O₅Si₂

: 704912-92-5
3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

Guidance literature:: C₃₂H₅₁BrCl₂O₅Si₂; With n-butyllithium; Trimethyl borate;

With sodium hydroxide; dihydrogen peroxide; Further stages.;
DOI:10.1016/j.tetlet.2004.02.154

Reference yield: 64.0%

: 704913-01-9
C₃₂H₅₁BrCl₂O₅Si₂

: 886054-92-8
1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene

: 704912-92-5
3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

Guidance literature:: C₃₂H₅₁BrCl₂O₅Si₂; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.05h;

With Trimethyl borate; In tetrahydrofuran; hexane; for 2h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; hexane; water; at 0 ℃;
DOI:10.1016/j.bmc.2005.11.055

Reference yield:

: 80373-18-8
3-(4'-hydroxyphenyl)-1-propyl acetate

: 704912-92-5
3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 64 percent / SO₂Cl₂ / 5 h / 0 °C

2.1: 100 percent / pyridine*HBr₃; pyridine / CHCl₃ / 3 h / 0 °C

3.1: 50 percent / LiClO₄ / Electrochemical reaction

4.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

5.1: 100 percent / DIPEA / CH₂Cl₂

6.1: 100 percent / K₂CO₃; MeOH / 20 °C

7.1: 100 percent / imidazole / dimethylformamide / 6 h

8.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

8.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

8.3: 64 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

With pyridine; 1H-imidazole; methanol; n-butyllithium; sulfuryl dichloride; pyridinium perbromide hydrobromide; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.055