1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
CAS No.:1092179-47-9
Molecular Formula:C₂₁H₁₉F₃N₂O₃
Molecular Weight:404.389
Hs Code.:

Synonyms:1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

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Technology Process of 1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

There total 7 articles about 1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: C₁₆H₁₄F₃NO₅

: 2393-23-9
4-methoxy-benzylamine

: 1092179-47-9
1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 73h;
DOI:10.1021/jm900411s

Reference yield:

: C₁₈H₁₈F₃NO₅

: 2393-23-9
4-methoxy-benzylamine

: 1092179-47-9
1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm101439s

Reference yield:

: 391-02-6
4-hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester

: 1092179-47-9
1-ethyl-N-(4-methoxybenzyl)-4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C

2: water; potassium hydroxide / Reflux

3: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C

4: 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; water; potassium carbonate; potassium iodide; potassium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm101439s