1-bromo-3-(chloromethyl)-2-fluorobenzene

Base Information

• Chemical Name: 1-bromo-3-(chloromethyl)-2-fluorobenzene
• CAS No.: 786652-60-6
• Molecular Formula: C7H5 Br Cl F
• Molecular Weight: 223.472
• Mol file: 786652-60-6.mol

Synonyms:1-bromo-3-(chloromethyl)-2-fluorobenzene

Chemical Property of 1-bromo-3-(chloromethyl)-2-fluorobenzene

Chemical Property:

• Melting Point: 59-61°
• PSA: 0.00000
• LogP: 3.32700

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2-fluorobenzylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-bromo-3-(chloromethyl)-2-fluorobenzene

There total 1 articles about 1-bromo-3-(chloromethyl)-2-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromo-2-fluoro-3-(hydroxymethyl)benzene (261723-32-4) → 1-bromo-3-(chloromethyl)-2-fluorobenzene (786652-60-6)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 90 ℃; for 0.5h;

Reference yield: 68.0%

1-bromo-3-(chloromethyl)-2-fluorobenzene (786652-60-6) + diethyl malonate (105-53-3) → diethyl (3-bromo-2-fluorophenyl)malonate (786652-61-7)

Guidance literature:

diethyl malonate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

1-bromo-3-(chloromethyl)-2-fluorobenzene; In tetrahydrofuran; Heating / reflux;

Reference yield:

1-bromo-3-(chloromethyl)-2-fluorobenzene (786652-60-6) + potassium cyanide (151-50-8) → 2-(3-bromo-2-fluoro-phenyl)acetonitrile (874285-03-7)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 2h;

upstream raw materials:

1-bromo-2-fluoro-3-(hydroxymethyl)benzene

Downstream raw materials:

2-(3-bromo-2-fluoro-phenyl)acetonitrile

diethyl (3-bromo-2-fluorophenyl)malonate

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