3-Bromo-2-fluorophenylacetonitrile

Base Information

• Chemical Name: 3-Bromo-2-fluorophenylacetonitrile
• CAS No.: 874285-03-7
• Molecular Formula: C8H5 Br F N
• Molecular Weight: 214.037
• Hs Code.: 2926907090
• Mol file: 874285-03-7.mol

Synonyms:3-Bromo-2-fluorophenylacetonitrile

Chemical Property of 3-Bromo-2-fluorophenylacetonitrile

Chemical Property:

• Vapor Pressure: 0.00346mmHg at 25°C
• Refractive Index: 1.551
• Boiling Point: 281.9°C at 760 mmHg
• Flash Point: 124.3°C
• PSA: 23.79000
• Density: 1.589 g/mL at 25 °C
• LogP: 2.65428
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-2-fluorophenylacetonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2-fluorophenylacetonitrile

There total 1 articles about 3-Bromo-2-fluorophenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3-(chloromethyl)-2-fluorobenzene (786652-60-6) + potassium cyanide (151-50-8) → 2-(3-bromo-2-fluoro-phenyl)acetonitrile (874285-03-7)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield: 80.0%

2-(3-bromo-2-fluoro-phenyl)acetonitrile (874285-03-7) + ethylene dibromide (106-93-4) → 1-(3-bromo-2-fluorophenyl)cyclopropane-1-carbonitrile

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2h;

Reference yield: 23.0%

(2S)-1-iodo-2-(2-iodoethoxy)propane (1159186-67-0) + 2-(3-bromo-2-fluoro-phenyl)acetonitrile (874285-03-7) → ((2S,4S)-4-(3-bromo-2-fluorophenyl)-2-methyl-tetrahydro-2H-pyran-4-carbonitrile) (1159186-80-7) + ((2S,4R)-4-(3-bromo-2-fluorophenyl)-2-methyl-tetrahydro-2H-pyran-4-carbonitrile) (1159186-79-4)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h;

upstream raw materials:

1-bromo-3-(chloromethyl)-2-fluorobenzene

potassium cyanide

Downstream raw materials:

4-(3-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile

((2S,4S)-4-(3-bromo-2-fluorophenyl)-2-methyl-tetrahydro-2H-pyran-4-carbonitrile)

((2S,4R)-4-(3-bromo-2-fluorophenyl)-2-methyl-tetrahydro-2H-pyran-4-carbonitrile)

(3-bromo-2-fluoro-phenyl)-acetic acid ethyl ester

Refernces