monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate

Base Information

• Chemical Name: monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate
• CAS No.: 948317-83-7
• Molecular Formula: C₂₃H₂₁NO₉P₂
• Molecular Weight: 517.369
• Mol file: 948317-83-7.mol

Synonyms:monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate

Chemical Property of monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate

There total 3 articles about monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-phthalimidopropionyl chloride (17137-11-0) + phenyl bis(trimethylsilyl) phosphite (137862-40-9) → monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate (948317-83-7)

Guidance literature:

at 20 ℃; for 6h;

DOI:10.1002/ejoc.200601067

Reference yield:

phthalic anhydride (85-44-9) → monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate (948317-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 6 h / 170 °C

2: 100 percent / oxalyl chloride / CH₂Cl₂ / 6 h / Heating

3: 50 percent / 6 h / 20 °C

With oxalyl dichloride; In dichloromethane;

DOI:10.1002/ejoc.200601067

Reference yield:

3-phthalimidopropanoic acid (3339-73-9) → monophenyl [3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-(hydroxy-phenoxy-phosphoryl)propyl]phosphonate (948317-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / oxalyl chloride / CH₂Cl₂ / 6 h / Heating

2: 50 percent / 6 h / 20 °C

With oxalyl dichloride; In dichloromethane;

DOI:10.1002/ejoc.200601067

upstream raw materials:

3-phthalimidopropionyl chloride

phenyl bis(trimethylsilyl) phosphite

phthalic anhydride

3-phthalimidopropanoic acid