ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate

Base Information

Chemical Name:ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate
CAS No.:1311229-08-9
Molecular Formula:C₂₅H₂₅ClN₂O₄
Molecular Weight:452.938
Hs Code.:

Synonyms:ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate

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Chemical Property of ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate

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Technology Process of ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate

There total 1 articles about ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.6%

: 1311267-07-8
(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)triphenylphosphonium chloride

: 87121-89-9
ethyl 3-oxocyclobutanecarboxylate

: 1311229-08-9
ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate

Guidance literature:: (4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)triphenylphosphonium chloride; With sodium hydride; In dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

ethyl 3-oxocyclobutanecarboxylate; In dimethyl sulfoxide; at 20 - 80 ℃; for 64.08h; Inert atmosphere;

Reference yield:

: 1311229-08-9
ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate

: 1311229-10-3
ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 1311229-08-9
ethyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzylidene)cyclobutanecarboxylate

: 1311231-88-5
3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

2: potassium hydroxide; water / ethanol / 16 h / 100 °C

With water; hydrogen; potassium hydroxide; palladium 10% on activated carbon; In ethanol; ethyl acetate;