methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate

Base Information

Chemical Name:methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate
CAS No.:1617501-38-8
Molecular Formula:C₁₇H₂₄ClNO₃
Molecular Weight:325.835
Hs Code.:

Synonyms:methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate

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Chemical Property of methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate

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Technology Process of methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate

There total 5 articles about methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: methyl 3-(((1r,4r)-4-aminocyclohexyl)oxy)-5-chloro-2-methylbenzoate trifluoroacetate

: 1617501-38-8
methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; for 1h;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1617501-38-8
methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione / 2 h

2.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

3.1: thionyl chloride / 0.25 h / Cooling with ice

3.2: 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 55 °C / Sealed tube; Microwave irradiation; Inert atmosphere

5.1: dichloromethane / 1 h

6.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h

With copper(l) iodide; 8-quinolinol; thionyl chloride; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; di-isopropyl azodicarboxylate; sulfuric acid; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 1549275-48-0
5-chloro-3-iodo-2-methylbenzoic acid

: 1617501-38-8
methyl 5-chloro-3-(((1r,4r)-4-(dimethylamino)cyclohexyl)oxy)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

2.1: thionyl chloride / 0.25 h / Cooling with ice

2.2: 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 55 °C / Sealed tube; Microwave irradiation; Inert atmosphere

4.1: dichloromethane / 1 h

5.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h

With copper(l) iodide; 8-quinolinol; thionyl chloride; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; tert-butyl alcohol;