diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate

Base Information

• Chemical Name: diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate
• CAS No.: 700380-65-0
• Molecular Formula: C₁₉H₂₈ClO₇P
• Molecular Weight: 434.854
• Mol file: 700380-65-0.mol

Synonyms:diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate

Chemical Property of diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate

There total 2 articles about diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-1 oxo-2 propylphosphonate de diethyle (101300-08-7) → diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate (700380-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / n-butyllithium; sodium hydride / tetrahydrofuran; hexane / 1 h / -78 °C

2: 82 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / -10 - 0 °C

With dmap; n-butyllithium; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.tet.2004.02.073

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate (700380-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / n-butyllithium; sodium hydride / tetrahydrofuran; hexane / 1 h / -78 °C

2: 82 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / -10 - 0 °C

With dmap; n-butyllithium; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.tet.2004.02.073

Reference yield: 44.0%

diethyl 1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate (700380-65-0) → diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(4-methoxyphenyl)butylphosphonate (700380-75-2) + diethyl (4S)-1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate (700380-70-7)

Guidance literature:

With magnesium chloride; Candida rugosa lipase; In di-isopropyl ether; water; at 30 ℃; for 48h;

DOI:10.1016/j.tet.2004.02.073

upstream raw materials:

chloro-1 oxo-2 propylphosphonate de diethyle

4-methoxy-benzaldehyde

Downstream raw materials:

diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(4-methoxyphenyl)butylphosphonate

diethyl (4S)-1-chloro-2-oxo-4-butyryloxy-4-(4-methoxyphenyl)butylphosphonate