methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate

Base Information

• Chemical Name: methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate
• CAS No.: 1222444-36-1
• Molecular Formula: C₂₁H₁₈BrClN₂O₃
• Molecular Weight: 461.743

Synonyms:methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate

Chemical Property of methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate

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Technology Process of methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate

There total 2 articles about methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl (1R,3S)-1-(2-bromophenyl)-2,3,4,9-tetrahydro-1H-bcarboline-3-carboxylate (528523-10-6) + chloroacetyl chloride (79-04-9) → methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate (1222444-36-1)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; at 20 ℃; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.ejmech.2009.10.046

Reference yield: 81.0%

→ methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate (1222444-36-1)

Guidance literature:

Reference yield: 37.0%

methyl (1R,3S)-1-(2-bromophenyl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate (1222444-36-1) + methylamine (74-89-5) → (6R,12aS)-6-(2-bromophenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione (1222444-42-9)

Guidance literature:

In methanol; for 16h; Reflux; Inert atmosphere;

DOI:10.1016/j.ejmech.2009.10.046

upstream raw materials:

methyl (1R,3S)-1-(2-bromophenyl)-2,3,4,9-tetrahydro-1H-bcarboline-3-carboxylate

chloroacetyl chloride

Downstream raw materials:

(6R,12aS)-6-(2-bromophenyl)-2-ethyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

(6R,12aS)-6-(2-bromophenyl)-2-butyl-2,3,6,7,12,12ahexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

(6R,12aS)-6-(2-bromophenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

(6R,12aS)-2-benzyl-6-(2-bromophenyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

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