ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate

Base Information

• Chemical Name: ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate
• CAS No.: 264881-90-5
• Molecular Formula: C₂₈H₃₀N₂O₄S
• Molecular Weight: 490.623
• Mol file: 264881-90-5.mol

Synonyms:ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate

Chemical Property of ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate

There total 3 articles about ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

dibenzo-1,4-thiazepin-11(10H)-thione (30690-43-8) + ethyl 3-(4-(2-aminoethoxy)phenyl)-2-ethoxypropionate (220746-95-2) → ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate (264881-90-5)

Guidance literature:

In various solvent(s); at 150 ℃; for 16h;

DOI:10.1021/jm010964g

Reference yield:

ethyl 2-ethoxy-3-(4-hydroxy-phenyl)-propionate (197299-16-4) → ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate (264881-90-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3.2 g / K₂CO₃ / butan-2-one / 48 h / Heating

2.1: potassium phthalimide / dimethylformamide / 16 h / 100 °C

2.2: 96 percent / hydrazine hydrate / ethanol / 2 h / Heating

3.1: 38 percent / various solvent(s) / 16 h / 150 °C

With potassium carbonate; potassium phtalimide; In N,N-dimethyl-formamide; butanone;

DOI:10.1021/jm010964g

Reference yield:

→ ethyl 3-(4-[2-(dibenzo[b,f]-1,4-thiazepin-11-ylamino)ethoxy]phenyl)-2-ethoxypropionate (264881-90-5)

Guidance literature:

upstream raw materials:

dibenzo-1,4-thiazepin-11(10H)-thione

ethyl 3-(4-(2-aminoethoxy)phenyl)-2-ethoxypropionate

ethyl 2-ethoxy-3-(4-hydroxy-phenyl)-propionate