3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one

Base Information

• Chemical Name: 3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one
• CAS No.: 1276544-41-2
• Molecular Formula: C₂₃H₂₆N₄O₃S
• Molecular Weight: 438.55
• Mol file: 1276544-41-2.mol

Synonyms:3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one

Chemical Property of 3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one

There total 5 articles about 3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-di(p-methoxyphenyl)-3-methylpiperidin-4-one (115584-11-7,138453-07-3) + thiosemicarbazide (79-19-6) + chloroacetic acid ethyl ester (105-39-5) → 3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one (1276544-41-2)

Guidance literature:

With silica gel supported sodium hydrogen sulphate; for 0.0333333h; Microwave irradiation;

DOI:10.3109/14756361003691878

Reference yield: 72.0%

chloroacetic acid ethyl ester (105-39-5) + C21H26N4O2S (597577-96-3) → 3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one (1276544-41-2)

Guidance literature:

With sodium acetate; In ethanol; for 4h; Reflux;

DOI:10.1016/j.bmcl.2009.11.074

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 3-(2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one (1276544-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / Heating

2: silica gel supported sodium hydrogen sulphate / 0.03 h / Microwave irradiation

With ammonium acetate;

DOI:10.3109/14756361003691878

upstream raw materials:

chloroacetic acid ethyl ester

C₂₁H₂₆N₄O₂S

2,6-di(p-methoxyphenyl)-3-methylpiperidin-4-one

thiosemicarbazide