3-(1-carboxy-ethyl)-phenyl boronic acid

Base Information

• Chemical Name: 3-(1-carboxy-ethyl)-phenyl boronic acid
• CAS No.: 1016644-45-3
• Molecular Formula: C₉H₁₁BO₄
• Molecular Weight: 193.995
• Mol file: 1016644-45-3.mol

Synonyms:3-(1-carboxy-ethyl)-phenyl boronic acid

Chemical Property of 3-(1-carboxy-ethyl)-phenyl boronic acid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-carboxy-ethyl)-phenyl boronic acid

There total 1 articles about 3-(1-carboxy-ethyl)-phenyl boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-bromophenyl)-propionic acid (53086-52-5) → 3-(1-carboxy-ethyl)-phenyl boronic acid (1016644-45-3)

Guidance literature:

2-(3-bromophenyl)-propionic acid; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.5h;

With boric acid tributyl ester; In diethyl ether; pentane; at -78 - 20 ℃; for 15h;

With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield: 86.0%

3-(1-carboxy-ethyl)-phenyl boronic acid (1016644-45-3) + carbon monoxide (201230-82-2) + Phenyl triflate (17763-67-6) → ketoprofen (22071-15-4,22161-86-0)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium(II) trifluoroacetate; In tert-butyl methyl ether; at 80 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/c6ra14678c

Reference yield: 83.0%

3-(1-carboxy-ethyl)-phenyl boronic acid (1016644-45-3) + carbon monoxide (201230-82-2) + toluene-4-sulfonic acid phenyl ester (640-60-8) → ketoprofen (22071-15-4,22161-86-0)

Guidance literature:

With palladium(II) trifluoroacetate; 1,2-bis-(diphenylphosphino)ethane; In N,N-dimethyl acetamide; at 80 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/c6ra14678c

upstream raw materials:

2-(3-bromophenyl)-propionic acid

Downstream raw materials:

ketoprofen

Refernces

• 1、 -. "2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIDIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS". Page/Page column 172-173. . Retrieved 2008/06/13.