diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

Base Information

Chemical Name:diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate
CAS No.:1232860-68-2
Molecular Formula:C₃₁H₃₅NO₆
Molecular Weight:517.622
Hs Code.:

Synonyms:diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

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Chemical Property of diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

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Technology Process of diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

There total 7 articles about diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16141-18-7
para-acetoxyphenylacetylene

: 1232860-66-0
diethyl 4,4′-(7-bromo-2-methyl-1H-indole-1,3-diyl)dibutanoate

: 1232860-68-2
diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In acetonitrile; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1232860-64-8
ethyl 4-(7-bromo-2-methyl-1H-indol-3-yl)butanoate

: 1232860-68-2
diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dimethyl sulfoxide / 16 h / 50 °C

2: diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile / 15 h / 20 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; diisopropylamine; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 50709-33-6
2-bromophenylhydrazine hydrochloride

: 1232860-68-2
diethyl 4,4'-(7-{[4-(acetyloxy)phenyl]ethynyl}-2-methyl-1H-indole-1,3-diyl)dibutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.67 h / 50 °C

1.2: 16 h / Reflux

2.1: caesium carbonate / dimethyl sulfoxide / 16 h / 50 °C

3.1: diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile / 15 h / 20 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; diisopropylamine; In ethanol; dimethyl sulfoxide; acetonitrile;