2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

Chemical Name:2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS No.:1354972-22-7
Molecular Formula:C₂₀H₂₃F₂N₅OS
Molecular Weight:419.498
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Chemical Property of 2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 5 articles about 2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39244-79-6
1-(thien-2-ylmethyl)piperazine

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1354972-22-7
2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: With triethylamine; In ethanol; for 8h; Reflux;
DOI:10.1016/j.ejmech.2013.04.025

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 1354972-22-7
2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 3 h / 40 °C

2: potassium carbonate / dichloromethane / 24 h / 20 °C

3: sodium hydroxide / toluene / 3 h / 60 °C

4: triethylamine / ethanol / 8 h / Reflux

With aluminum (III) chloride; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2013.04.025

Reference yield:

: 51336-94-8
2-chloro-1-(2,4-dichlorophenyl)ethanone

: 1354972-22-7
2-(2,4-difluorophenyl)-1-(4-(thiophen-2-ylmethyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloromethane / 24 h / 20 °C

2: sodium hydroxide / toluene / 3 h / 60 °C

3: triethylamine / ethanol / 8 h / Reflux

With potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2013.04.025