4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Base Information

Chemical Name:4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde
CAS No.:141667-43-8
Molecular Formula:C₂₁H₂₉NO₅SSi
Molecular Weight:435.616
Hs Code.:

Synonyms:4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Suppliers and Price of 4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

There total 4 articles about 4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 141667-31-4
3-[(tert-butyl)dimethylsilyloxy]-1-[(4-methylphenyl)sulfonyl]-1H-pyridin-2-one

: 107-02-8,25068-14-8
acrolein

: 141667-43-8
4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Guidance literature:: With 2,6-di-tert-butyl-4-methyl-phenol; In dichloromethane; at 90 ℃; for 148h;
DOI:10.1021/jo00041a010

Reference yield:

: 16867-04-2
dihydroxypyridine

: 141667-43-8
4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / imidazole / dimethylformamide / 3 h

2: 1) MeLi / 1) Et₂O, 2) Et₂O

3: 70 percent / BHT / CH₂Cl₂ / 148 h / 90 °C

With 1H-imidazole; 2,6-di-tert-butyl-4-methyl-phenol; methyllithium; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00041a010

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 141667-43-8
4-<(tert-butyldimethylsilyl)oxy>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5-endo-carboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / imidazole / dimethylformamide / 3 h

2: 1) MeLi / 1) Et₂O, 2) Et₂O

3: 70 percent / BHT / CH₂Cl₂ / 148 h / 90 °C

With 1H-imidazole; 2,6-di-tert-butyl-4-methyl-phenol; methyllithium; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00041a010