(R)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate
• CAS No.: 783325-25-7
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.308
• Hs Code.: 2933990090
• European Community (EC) Number: 848-567-0
• DSSTox Substance ID: DTXSID90692897
• Wikidata: Q72487155
• Mol file: 783325-25-7.mol

Synonyms:783325-25-7;(R)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate;tert-butyl (2R)-2-(methylaminomethyl)pyrrolidine-1-carboxylate;(R)-1-Boc-2-(Methylaminomethyl)pyrrolidine;(R)-tert-butyl2-((methylamino)methyl)pyrrolidine-1-carboxylate;tert-Butyl (2R)-2-[(methylamino)methyl]pyrrolidine-1-carboxylate;tert-butyl (R)-2-((methylamino)methyl)pyrrolidine-1-carboxylate;SCHEMBL5109143;DTXSID90692897;MFCD07786198;AKOS015909218;DS-6824;CS-0135253;(R)-1-Boc-2-(N-methylaminomethyl)pyrrolidine;A26519;O10185;EN300-4757886;(R)-t-Butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylicacid,2-[(methylamino)methyl]-,1,1-dimethylethyl ester,(2R)-

Chemical Property of (R)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate

Chemical Property:

• Boiling Point: 282℃
• Flash Point: 124℃
• PSA: 41.57000
• Density: 1.004
• LogP: 1.93410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 214.168127949
• Heavy Atom Count: 15
• Complexity: 223

Purity/Quality:

98%min ^*data from raw suppliers

(R)-1-Boc-2-(Methylaminomethyl)-pyrrolidine 96 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCCC1CNC
• Isomeric SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1CNC

Technology Process of (R)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate

There total 4 articles about (R)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester (785825-41-4) + methylamine (74-89-5) → (R)-2-methylaminomethyl-1-BOC-pyrrolidine (783325-25-7)

Guidance literature:

2-methylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

methylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 100.0%

2-methylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester (785825-41-4) → (R)-2-methylaminomethyl-1-BOC-pyrrolidine (783325-25-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/jm0498396

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + methylamine (74-89-5) → (R)-2-methylaminomethyl-1-BOC-pyrrolidine (783325-25-7)

Guidance literature:

1-(tert-butoxycarbonyl)-L-proline; methylamine; With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; at 20 ℃; for 18h;

With borane tetrahydrofuran; In tetrahydrofuran; at 20 ℃; for 18h;

upstream raw materials:

2-methylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester

N-(tert-butoxycarbonyl)-D-proline

1-(tert-butoxycarbonyl)-L-proline

methylamine

Refernces

• 1、 -. "TRIAZOLO[1,5-C]PYRIMIDINES and PYRAZOLO[1,5-C]PYRIMIDINES AND METHODS OF MAKING AND USING THE SAME". Page 24-25. . Retrieved 2010/02/09.
• 2、 -. "TRIAZOLO[1,5-A]PYRIMIDINES and PYRAZOLO[1,5-A]PYRIMIDINES AND METHODS OF MAKING AND USING THE SAME". Page 24-25. . Retrieved 2010/02/09.