(S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate

Base Information

Chemical Name:(S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate
CAS No.:1257443-90-5
Molecular Formula:C₂HF₃O₂*C₃₂H₃₆N₂O₅
Molecular Weight:642.672
Hs Code.:

Synonyms:(S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate

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Chemical Property of (S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate

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Technology Process of (S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate

There total 7 articles about (S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257443-91-6
(S)-1-tert-butoxycarbonylmethyl-pyrrolidine-2-carboxylic acid benzyl ester

: 1257443-01-8
ethyl (R)-3-amino-4-(biphenyl-4-yl)butyrate hydrochloride

: 76-05-1
trifluoroacetic acid

: 1257443-90-5
(S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate

Guidance literature:: (S)-1-tert-butoxycarbonylmethyl-pyrrolidine-2-carboxylic acid benzyl ester; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

ethyl (R)-3-amino-4-(biphenyl-4-yl)butyrate hydrochloride; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 4h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: (S)-benzyl 1-(2-tert-butoxy-2-oxoethyl)pyrrolidine-2-carboxylate

: (R)-ethyl 3-amino-4-(biphenyl-4-yl)butanoate hydrochloride

: 25952-53-8
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

: 1257443-90-5
(S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate

Guidance literature:: With triethylsilane; DIPEA; HOAt; trifluoroacetic acid; In water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 80089-24-3
benzyl prolinate hydrochloride

: 1257443-90-5
(S)-benzyl 1-(2-((R)-1-(biphenyl-4-yl)-4-ethoxy-4-oxobutan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide; water

2: trifluoroacetic acid; triethylsilane; DIPEA; HOAt / N,N-dimethyl-formamide; acetonitrile; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With triethylsilane; DIPEA; HOAt; potassium carbonate; trifluoroacetic acid; In water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide; acetonitrile;