(4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

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Chemical Name:(4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone
CAS No.:1014701-08-6
Molecular Formula:C₃₁H₃₇F₄N₅O₂
Molecular Weight:587.661
Hs Code.:

(4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

Synonyms:(4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

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Chemical Property of (4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

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Technology Process of (4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

There total 9 articles about (4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: C₂₆H₃₄FN₅O*6ClH

: 277756-46-4
1-(trifluoromethyl)cyclopropanecarboxylic acid

: 1014701-08-6
(4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 1014701-08-6
(4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: copper(l) iodide / tetrahydrofuran / 3 h / 0 °C

2.1: sodium hydroxide / ethanol; water / 15 h / 20 °C

2.2: 0 °C / pH 3

3.1: copper(I) oxide / acetonitrile / 1 - 1.25 h / Heating / reflux

4.1: diisobutylaluminium hydride / dichloromethane / 4 h / -78 - -60 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / ethanol / 21 h / 20 °C / 760.05 Torr

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

8.1: hydrogenchloride / 1,4-dioxane; methanol; diethyl ether / 5 h / 20 - 40 °C

9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With copper(I) oxide; hydrogenchloride; sodium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; copper(l) iodide; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 878130-44-0
4-(3-fluoro-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1014701-08-6
(4,6-dimethyl-pyrimidin-5-yl)-(5-{2-[4-(3-fluoro-phenyl)-1-(1-trifluoromethyl-cyclopropanecarbonyl)-piperidin-4-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

2: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / ethanol / 21 h / 20 °C / 760.05 Torr

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol; diethyl ether / 5 h / 20 - 40 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane;