1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one
CAS No.:161443-31-8
Molecular Formula:C₂₄H₂₁N₃O₃
Molecular Weight:399.449
Hs Code.:

Synonyms:1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

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Chemical Property of 1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

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Technology Process of 1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

There total 5 articles about 1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 110884-69-0
Carbonic acid 4-nitrophenyl (R)-1-phenylethyl diester

: 103343-47-1
3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

: 161443-31-8
1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

: 1,3-Dihydro-5-phenyl-3(R)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

Guidance literature:: With triethylamine; In acetonitrile; Yields of byproduct given; Heating;
DOI:10.1021/jo00108a044

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 161443-31-8
1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: Et₃N / acetonitrile / Heating

With pyridine; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo00108a044

Reference yield:

: 108895-98-3
benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

: 161443-31-8
1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / HBr / acetic acid / 1.) 70 deg C, 20 min, 2.) 80 deg C, 20 min

2: Et₃N / acetonitrile / Heating

With hydrogen bromide; triethylamine; In acetic acid; acetonitrile;
DOI:10.1021/jo00108a044