(R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide

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Chemical Name:(R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide
CAS No.:1316100-17-0
Molecular Formula:C₃₄H₃₈N₂O₄
Molecular Weight:538.687
Hs Code.:

Synonyms:(R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide

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Chemical Property of (R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide

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Technology Process of (R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide

There total 9 articles about (R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188690-82-6
(R)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol

: 1316100-17-0
(R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / toluene; methanol / 20 h / 40 °C

2.1: 20 h / 140 °C / Inert atmosphere

3.1: hydrogen / Ni-Raney / isopropyl alcohol; toluene / 20 h / 40 °C / 13680.9 Torr

4.1: acetic anhydride / 2 h / 50 °C / Inert atmosphere

4.2: 1 h / 0 °C

4.3: 0.25 h / 0 °C

With hydrogen; acetic anhydride; potassium carbonate; Ni-Raney; In methanol; isopropyl alcohol; toluene;

Reference yield:

: 64-18-6
formic acid

: 1315510-05-4
(R,R)-1-(3-amino-4-benzyloxy-phenyl)-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethanol

: 1316100-17-0
(R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide

Guidance literature:: formic acid; With acetic anhydride; at 50 ℃; for 2h; Inert atmosphere;

(R,R)-1-(3-amino-4-benzyloxy-phenyl)-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethanol; In dichloromethane; at 0 ℃; for 1h;

With potassium carbonate; In dichloromethane; water; at 0 ℃; for 0.25h;

Reference yield:

: 188730-94-1
(R)-1-(4-benzyloxy-3-nitrophenyl)oxirane

: 1316100-17-0
(R,R)-N-(2-benzyloxy-5-{1-hydroxy-2-[[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amino]-ethyl}-phenyl)-formamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20 h / 140 °C / Inert atmosphere

2.1: hydrogen / Ni-Raney / isopropyl alcohol; toluene / 20 h / 40 °C / 13680.9 Torr

3.1: acetic anhydride / 2 h / 50 °C / Inert atmosphere

3.2: 1 h / 0 °C

3.3: 0.25 h / 0 °C

With hydrogen; acetic anhydride; Ni-Raney; In isopropyl alcohol; toluene;