2'-(Trifluoromethylthio)acetophenone

Base Information

• Chemical Name: 2'-(Trifluoromethylthio)acetophenone
• CAS No.: 240408-91-7
• Molecular Formula: C₉H₇F₃OS
• Molecular Weight: 220.215
• DSSTox Substance ID: DTXSID901263226

Synonyms:240408-91-7;2'-(Trifluoromethylthio)acetophenone;1-{2-[(trifluoromethyl)sulfanyl]phenyl}ethan-1-one;1-[2-(trifluoromethylsulfanyl)phenyl]ethanone;DTXSID901263226;MFCD00236330;1-[2-[(Trifluoromethyl)thio]phenyl]ethanone;EN300-300067

Chemical Property of 2'-(Trifluoromethylthio)acetophenone

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 220.01697050
• Heavy Atom Count: 14
• Complexity: 215

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=CC=C1SC(F)(F)F

Technology Process of 2'-(Trifluoromethylthio)acetophenone

There total 4 articles about 2'-(Trifluoromethylthio)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-iodoacetophenone (2142-70-3) + silver(I) trifluoromethanethiolate (811-68-7) → 1-(2-((trifluoromethyl)thio)phenyl)ethanone (240408-91-7)

Guidance literature:

With 1,10-Phenanthroline; copper(I) bromide; In acetonitrile; at 80 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/ol501742a

Reference yield: 92.0%

2-bromophenyl methyl ketone (2142-69-0) + tetramethylammonium trifluoromethanethiolate → 1-(2-((trifluoromethyl)thio)phenyl)ethanone (240408-91-7)

Guidance literature:

With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In toluene; at 80 ℃;

DOI:10.1002/anie.201501617

Reference yield: 82.0%

2-iodoacetophenone (2142-70-3) + (2,2'-bipyride-kN1,kN1')(1,1,1-trifluoromethanethiolato-kS)-copper (1413732-47-4) → 1-(2-((trifluoromethyl)thio)phenyl)ethanone (240408-91-7)

Guidance literature:

In acetonitrile; for 15h; Inert atmosphere; Sealed tube; Heating;

DOI:10.1002/anie.201208432

upstream raw materials:

2-iodoacetophenone

(2,2'-bipyride-kN₁,kN₁')(1,1,1-trifluoromethanethiolato-kS)-copper

silver(I) trifluoromethanethiolate

2-bromophenyl methyl ketone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 240408-91-7 1-(2-((trifluoromethyl)thio)phenyl)ethanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send